Animal Biotechnology in Developing Countries

physical biotech in Developing Countries physical BIOTECHNOLOGY FOR THE DEVELOPING COUNTRIES APPLICATIONS, RISKS AND ETHICS TO BE CONSIDEREDABSTRACTIn mass of the maturation countries, the application of bioengineering associated to inventory has to be appropriate for the animated creature owners who lack re beginnings and who read little land and few living creatures. caudex is enough proudly necessity for the development countries in terms of stinting growth, whole life style and socio-economic objectives. Livestock employment is col cut intoated with applied science for viable agriculture. Livestock is an integral part of the ecosy alkali and is an abundant seeded player of creature biodiversity since local breeds attain genes and characteristics that be of bang-up pry. Molecular markers be utilised to a great extent to determine and choose certain genes having desired characteristics and to spread its ingestion in artificial insemination, embryo exc hange and various former(a) procreative methods. These technologies are utilise extensively in patrimonial growment of the neckcloth such as in cows and buffaloes. Presently, biotechnology is employ for the give awayturn of vaccines and diagnostic kits. How of all time, in the absence of proper foundation, inappropriate manpower, inadequate livelihood to conjureers and lacking of usable resources, still in that respect is lot gap in the field. In spite of having many advantages, there are several find factors and estimable issues to be considered in genetically modifying animate beingnesss for forgiving consumption and wildcat welfare. This paper deals with the problems faced by the ontogeny countries, applications of animal biotechnology to deluge these problems, trys involved and ethical principles to be considered.INTRODUCTIONBiotechnology is considered to be necessary for the human survival and as a tool that give enhance the quality of life of the peo ple in the world 1. Genomics and biotechnology has a long skill to combat diseases that mostly affect the worlds poorest population 2. Although biotechnology is assumed to elevate the life of the person in the world and allow a more comfortable living, commercial considerations and socioeconomic goals that are believed by the society are very important 3. Animal biotechnology is the application of scientific and engineering principles to the processing or work of materials by animals or aquatic species to put up goods and services. The doing of fund is expanding when compared to any oppositewise sector and by the year 2020, the stock certificate is so-called to turn over the most signifi trickt agricultural sector. The application of biotechnology in this sector will direct to a substantiative shift in the economic returns from broth. 43% of the agricultural production is by means of the production of livestock where more than half of the agricultural yield is from t he livestock of the developed countries and sensation third is from the underdeveloped countries.PROBLEMS FACED BY THE DEVELOPING COUNTRIESAdvantages of biotechnology pay only reached the developed countries, with billions in the poor countries macroscopically excluded from these clears. The practice of employ the molecular biotechnologies and the novel breeding principles to the livestock animals by the developing countries is agonistic by various factors. Dearth, mal regimen, inadequate hygiene and unemployment are common in the developing countries and techniques related to biotechnology do to be applied on a pooh-pooh floor these circumstances. Green revolution has been effective for farmers who have land solely farmers who do not have land exist only on livestock and they have been condemned and remained poor. I think developing countries should be able to authorise these techniques with the help of government agencies which would help make better their quality of l ife and living by considering the ethical, social and milieual issues into account.In developing economics, the livestock has become very necessary for the expansion of agriculture. The quest for the products from livestock is the function of income and sustained improvement in the per capita income, increasing urban population and the alterations in the life style and diet are improving the growth in production of livestock.By increasing the income and employment and by depreciating the clownish poverty, the production of livestock leads to socioeconomic culture. The function of livestock is not only to provide pabulum and nutrition but also acts as a supply in draught power and organic manure. Therefore livestock is necessary source of income and address the unemployment issue. This helps in reducing the poverty and scatters the income among the rural population that constitutes small landholders and a most of the livestock owners. During unfavorable environments, livestock burn down be reverted into cash and therefore can be used during crop failure. sizeableness OF TECHNOLOGYAnimal biotechnology has various uses. Transgenic animals with alter growth consec sets, change lean muscle mass, great resistance to disease have been produced ever since the early 1980s 4. Genetic content of animals such as poultry, swine, goats and cattle have been circumscribed so that they produce more amounts of human proteins in eggs, take out, blood and urine which helps in devising of human pharmaceuticals. This therapeutics contains proteins required for public such as enzymes, clotting factors, albumin and antibodies. awe are genetically modified by injecting a bacterium containing growth horm 1 called bovine somatotropin (BST) to increase the take out production rate by 10 to 15 percent.Considerable number of genes and desired traits has been discovered in the livestock of Africa and Asia. Examples of such breeds from these continents are significant in t he world(a) level such as, buffaloes that yield milk with more amounts of fat and with greater quality of protein necessary for the production of mozzarella cheese, goats from cold countries that stick pashmina and toos- slender varieties of wool, Black Bengal goats that bear genes for high productivity, Garole sheep that bear genes for twinning and sheeps, camels and goats that are tolerant to tropical arid environment and can sustain feed with high lignin reputation. Milk, meat and eggs production and the nutritional value, pr in timetion of diseases and healthcare has been amend for these products through the use of biotechnology. Biotechnology is a new developing tool for the growth of agricultural technologies.The greater profit of agricultural look into and technology is that the poor can secure the products easily since both(prenominal) the average incomes and the use of these intellectual nourishment products are improved 3. The improvement in the production of livest ock has called for an increased value of land, labor and goods and services of non-agricultural origin therefore improving the overall growth in the economy. The rural population spends nearly greater part of their additional income on viands. Therefore biotechnology can be applied to livestock production which leads to a greater nutritional significance in case the technology is aimed at the poorest producers. However, commercialization of agriculture has depleted the nutritional security of the rural population.APPLICATIONS OF THE TECHNOLOGYThere are many technologies that have been evolved to the livestock of both developing and developed countries. However, the large scale technologies that are efficiently utilized in the production of livestock in the developing countries comprises of protecting the animal genetic resources, enhancing reproduction, embryo impart (ET), detecting and reducing diseases and increasing the nutrition value.1. TransgenicsGene related technologies ha ve the tendency to boost the ability for the production of livestock thereby assuring larger profits for the farmers 2. The global adaption of genetically modified (GM) crops, which were grown on 67.7 million hectares in 2003 compared with 2.8 million hectares in 1996, has had a greater impact on livestock feed. It is estimated that the United States of America, Argentina, Canada, brazil-nut tree and the Peoples Republic of China have 63%. 21%, 6%, 4% and 4% respectively, of the global transgenic acreage and that the most often grown crops are GM soybean (61%), maize (23%), cotton (11%) and canola (5%). Although explore in medical field requires the use of transgenic animals such as mice, GM animals have not yet been discharged into the farms 3. The progress in the genetic alteration of the livestock is very slow when compared to the genetic alteration of crops for a wide range of reasons that include high costs, inappropriate gene transfer techniques and small fruitful rates of animals. Recombinant deoxyribonucleic acid (DNA) techniques play to the expression of desires genes, to suppress the expression of unwanted genes, to modify certain genes to obstruct certain pathways. It was decided that approximately 30 enzymes are produced from GM bacterium, yeasts and moulds that are commercially available and most of these enzymes are utilized in the food industry.Milk produced from transgenic cattle has the ability to improve the production of some proteins or growth factors and this improved quality in the nutrient and therapeutic content in the subject of milk may have a greater impact on the development and the survival of the newborn humans and animals. This transgenic alteration in the milk will lead to a greater utilization of milk and milk products in the fields of both agriculture and medicine. By improving the composition of the proteins in milk or developing a new protein in the milk is a value added opportunity for transgenic agriculture.2. clo neNuclear copy is the process of creating new animals by introducing somatic nuclei into an unfertilized oocyte 5. In other words it is the process in which one single DNA shred can give rise to an entire organism 6. Even though it was started in fishes to know the nuclear totipotency, it was extended for higher organisms like sheep where wench was the first cloned mammal. Genetically modified nuclear transfusion can take over a better role in clone with desired characteristics. Since it is a prison cell medicated transfer addition and deletion of the specific gene can be done depending on the gene of interest that is to be produced. Cloning can be used in preservation of indigenous breeds of global zoo pool which are adapted to a local environment. times can be done rapidly which give uniform clones. This technology can be used as a therapeutic mover for several diseases like diseases like diabetes, spinal disorders and tissue damage by using the transplanted cells to replac e the damaged tissue or using stem cells to differentiate into the specific cells of interest. Cloned animals can be used as research models which give identical twins that have same pathway for their physiologic activities rather than using animals with more genetic variability. It improves the quality and quantity of food products produced and also produces several disease resistant plants that reduce pollution indirectly.3. staged insemination (AI)Artificial insemination (AI) is a method by which sperm from male is collected, processed and stored and then is artificially inserted into the effeminate reproductive tract for conception. AI is one of the most essential procedures for genetically improving farm animals and is extensively used for breeding dairy. 7. The recognition of AI method worldwide presents the development of other technologies, such as cryopreservation and sexing of sperm, estrous cycle regulation, and embryo harvesting, freezing, culture and transfer, and c loning 8.The rate of conception in the area of AI in the developing countries is slight and hence the desired efficiency on the animal development has not been accomplished. Artificial insemination has following advantages over natural breeding. The major benefit of AI is that it makes utmost use of superior sires. Earlier, very few could vanquish the benefit of superior bulls. Naturally, a bull can be bred to 50 to 60 cows per year. In contrast, by AI, thousands of cows can be sired in one year by one bull. 9. Exposure of sires to contractable genital infections is prevented by utilizing AI thereby preventing the spread of such infections.4. embryo transfer (ET)To obtain genetically superior or important animals, animal breeders are attempting to get as many offsprings as possible. Hormonal induction of multiple ovulations, followed by non-surgical collection of embryos and embryo transfer is extensively used 10.ET is one of the most important reproductive techniques in cattle that can elevate the genetic improvement. ET in cattle has tardily acquired vast popularity with seedstock dairy and beef producers. Like artificial insemination, ET can importantly increase the number of offsprings 11.ET improves the reproductive ability of a cow because cum from one male can be utilized for a huge number of females, and by using a technique called superovulation, superior female can be make to provide more number of ovules. Cows that are not capable of sustaining maternity can still contribute by providing ovules for ET. Embryos can also be frozen and preserved in an embryo bank and used whenever required 12.5. In vitro production of embryosIn vitro production (intravenous pyelogram) of buffalo embryos has gained an importance because of less acceptance of AI and reduced superovulatory response in buffaloes 13. IVP contributes a good supply of embryos for studying fundamental research on developmental physiology, farm animal breeding, embryo sexing, sperm injec tion, nuclear transfer, cloning and transgenesis. IVP leads to a favorable pregnancy and birth of the calf in buffalo. However, the rate of success if less. Therefore IVP must be enhanced in the developing countries before it can be used in the cattle as well as buffaloes.6. Improving health through vaccinesVaccines are used for the prevention and verify of animal and human diseases 14. Through biotechnology, new and enhanced doses have been produced that lower production expenses and increase animal welfare by combating infections caused by bacteria and parasites 15.With the help of modern biotechnology techniques, new and improved animal vaccines have also been generated. Vaccines used to fight diseases such as foot and verbalise disease, scours, brucellosis, shipping fever, feline leukemia and rabies. Test kits have been created to diagnose health of livestock and other animals. Molecular biology distinguishes the disease causing agents by sequencing the nucleotides and by det ermining the origin of these pathogens. These molecular diagnostic techniques are polymerase chain reply (PCR), monoclonal antibodies and recombinant antigens. These approaches can be made better to promote their use in the developing countries.RISKS OF ANIMAL BIOTECHNOLOGYAlthough implementing this technology provides many benefits, there are also certain risks involved with this technology 18.Genetically modified animals interfere with nature and tend to affect normal wild reference organismsGenetic diversity of organisms is narrowed down and existing modifies animals will be prone to diseases and threatened as a result.The preventative of food containing or produced from engineered animals also raises questions in the public because of its unpredictability (toxic or allergic etc)It has huge impact on the normal farms and their employment.To start up the business, funds are essential which might be obtained from government or private enterprises which is dubitable due to lack of trust.It leads to Negative Globalization which is due to probable mistreatment of developing countries.There is also scope for mistreatment of animals causing stress and future abnormalities which will be op reposed by animal welfare organizations like PETA (People for the honest Treatment of Animals) etc.Procedures like cloning will reduce by nature occurring genetic variability.Animal biotechnology involves costly processes but the success rate is very lessThere might be transfer of pathogens and other disease causing organisms from the donors to recipient animals.The life expectancy of such animals even after spending both time and money is very less as they are subjected to strain to produce more and desirable products.Techniques such as embryonic cell nuclear transfer (ECNT) and somatic cell nuclear transfer (SCNT) have raised apprehensions on human safety and animal health. The cloned animals tend to have a poor success rate for embryo development which is called as large offspring syndrome 19, placental abnormalities, edema, large umbilicus or perinatal deaths.Concerns still exist on the human consumption of cloned animals.Several other moral and ethical concerns also pose risks in the use of animal biotechnology.ETHICAL CONSIDERATIONS OF THE TECHNOLOGYToday, ethical, social, environmental and economic issues in animal farming are essentially associated with sustainable income and food security for millions of people in the developing countries 16. The major function of farm animals in social, cultural and economic welfare of humanity in the developing countries contrasts with the condition in developed countries. Basically, there are two areas of ethical considerations. One being the alterations in the genetic content of animals and the other being concerns on animal welfare. Animals are considered to be voiceless victims of science since the fearsome treatment given to these animals during slaughtering and transportation is contrast of the perce ived sentiments and love for animals. good considerations should be regarded on gene establish methods such as gene product that has its application in vaccination, genes used for treatment of diseases and to detect the source of infections and making of therapeutic agents through insertion of specific genes into living tissues. estimable and social examination on the biosafety issues such as harm in the recipient animals and humans who consume transgenic products should be considered.Although transgenic methods such as universe of a gene to get a desired trait, modification of physiological development and functions, increased reproductive capability, disease resistant animals prove to be of great benefit to the humans, biosafety, environmental risks should not be neglected. According to Monsanto which is an agrochemical company, bovine somatotropin is a natural protein supplement that improves the cows ability to produce milk 17. However, some organizations believe that Monsanto is pushing a drug that compels cows to work harder on the factory cattle farm, and that pollutes ordinary processes. relate disapproval has been observed against attempts to genetically altering animals so that they will generate high levels of growth hormone.Animal welfare and animal rights are oft de bear downd in most of the developing countries. Certain laws such as anti-cruelty law and animal protection law should be adapted by all the countries so that animals are considered to have a fundamental value and are not solely instrumental for humans. Research should still be conducted to provide a safer and cheaper way of embryo transfer and artificial insemination in the developing countries.CONCLUSIONS AND REMEDIESProgress in the development of biotechnology is being made in many countries. However, only a small proportion of it is scope the developing countries in the fields of conservation, animal improvement, diagnosis and control of diseases. However, farmers are not bene fitted from the gene based techniques. Accessing novel technologies is very expensive for the developing countries and there is less investment for animal health and production. Although many discoveries have been developed in the laboratories by the developing countries, majority of them are not modified into appropriate products. Sufficient national and international platform through international donor consortium is required to manage the cost to door the biotechnological products. In the developing countries, the money expended by the international organizations on animal biotechnology is insufficient. The World Bank, the Food and Agriculture Organization, the Consultative Group on external Agricultural Research, the United Nations Development Programme, The United States Agency for International Development, The Swedish International Development Cooperation Agency, the International Development Research Centre, the Asiatic Development Bank and many such groups have to provide greater funds to the livestock sector. Contributing money in livestock has positive results in human development.I think, by identifying the health needs and making use of the benefits of these technologies, developing countries can exploit biotechnology for enhancing human health. However, the risk factors and ethical issues should be considered not only by the developing countries but also by the developed countries. More studies and research has to be conducted to sully the risks of applying these technologies. The government agencies should provide proper finance to apply these technologies and also provide trained labor to get a maximum benefit out of it.REFERENCEShttp//www.csrees.usda.gov/nea/biotech/in_focus/biotechnology_if_animal.htmlDaar, et al (2007), Hoe can developing countries harness biotechnology to improve health? BMC Public Health, 7346.M.L. Madan, Animal biotechnology applications and economic implications in developing countries (2005), Rev. sci. tech. Off. Int . Epiz., 24(1), 127-139.http//www.aboutbioscience.org/pdfs/Animal_Biotechnology.pdfhttp//www.epidna.com/showabstract.php?pmid=11985609redirect=yesterms=define+nuclear+cloningWells, 2005., Animal Cloning problems and prospects, Rev. Sci. tech.int. Epiz, 24(1),251-264.http//edis.ifas.ufl.edu/DS089Foote (2002), The fib of artificial insemination Selected notes and notables, journal of animal science, 801-10http//www.world-agriculture.com/animalhusbandry/artificial_insemination_cattle.phpHashimoto (2009), applications of invitro maturation to assisted reproductive technology, journal of reproduction and development, 55, 1.http//www.brangusworld.com/documents/Estrus%20Sinchonization.pdfhttp//www.molecular-plant-biotechnology.info/in-vitro-fertilization-and-embryo-transfer-in-humans-and-livestock/advantages-of-embryo-transfer-in-cattle.htmNandi S et al., Production of Buffalo (Bubalus bubalis) Embryos in virto Premises and Promises (2002), Reprod Dom Anim 37, 65-74.Kurstak et al., Toward s new vaccine and modern vaccinology introductory remarks (1999), Elsevier- Vaccine 17, 1583-1586file///G/443-003.htmlKesavan (2005), et al., Ethical, Social, Environmental and Economic issues in Animal Biotechnology, Applications of gene based technologies for improving animal production and health in developing countries, 447-462.Levidow et al., (1997), How biotechnology regulation sets a risk/ethics boundary, Agriculture and human values, 14 29-43http//ucbrep.ucdavis.edu/PDFs/Animal%20biotech%20Food%20Expo.pdfYang et al., (2007), Risk assessment of meat from cloned animals, Nature biotechnology, vol 25, no. 1.